@media (max-width: 767px){#tools[data-astro-cid-sz7xmlte]{position:fixed!important;inset:auto 0 0!important;transform:none!important;width:100%!important;max-width:100%!important;height:auto!important;background-color:#010326!important;box-shadow:0 -2px 10px #0000004d!important;padding:6px 0!important;display:flex!important;flex-direction:row!important;justify-content:space-evenly!important;align-items:center!important;gap:0!important;border-radius:0!important;margin:0!important}#tools[data-astro-cid-sz7xmlte] a[data-astro-cid-sz7xmlte]{display:flex!important;justify-content:center!important;align-items:center!important;flex:1!important;padding:2px!important}#tools[data-astro-cid-sz7xmlte] a[data-astro-cid-sz7xmlte] img[data-astro-cid-sz7xmlte]{width:35px!important;height:35px!important}}.hotspot-v2[data-astro-cid-sqcmh2cm]{--color-cita: #eee;--color-sonar: #f01b18;--tam-sonar: 15px;--max-width: 650px;--container-width: 80%;font-family:Open Sans,sans-serif;font-size:1em;-webkit-user-select:none;-moz-user-select:none;-ms-user-select:none;user-select:none;width:var(--container-width);max-width:var(--max-width);margin:2em auto}.hotspot-v2-header[data-astro-cid-sqcmh2cm]{margin-bottom:1.5em;text-align:center}.hotspot-v2-header[data-astro-cid-sqcmh2cm] h3[data-astro-cid-sqcmh2cm]{margin-bottom:.5em}.hotspot-v2-container[data-astro-cid-sqcmh2cm]{position:relative;width:100%;margin:0 auto;background-color:#fff;box-shadow:0 0 0 10px #fff,0 15px 50px #0000004d}.hotspot-v2-container[data-astro-cid-sqcmh2cm] img[data-astro-cid-sqcmh2cm]{display:block;height:auto;width:100%}.hotspot-v2-overlay[data-astro-cid-sqcmh2cm]{position:absolute;height:100%;width:100%;left:0;top:0;pointer-events:none}.hotspot-v2-point-wrapper[data-astro-cid-sqcmh2cm]{position:absolute;transform:translate(-50%,-50%);pointer-events:all;z-index:100;isolation:isolate}.hotspot-v2-point-wrapper[data-astro-cid-sqcmh2cm]:hover,.hotspot-v2-point-wrapper[data-astro-cid-sqcmh2cm]:focus-within{z-index:3000}.hotspot-v2-pin[data-astro-cid-sqcmh2cm]{position:relative;margin:0;padding:0;height:var(--tam-sonar);width:var(--tam-sonar);background-color:var(--color-sonar);border:none;border-radius:50%;cursor:pointer;z-index:10;display:block}.hotspot-v2-pin[data-astro-cid-sqcmh2cm]:focus{outline:2px solid var(--color-sonar);outline-offset:3px}.sr-only[data-astro-cid-sqcmh2cm]{position:absolute;width:1px;height:1px;padding:0;margin:-1px;overflow:hidden;clip:rect(0,0,0,0);white-space:nowrap;border-width:0}.hotspot-v2-pin[data-astro-cid-sqcmh2cm]:before,.hotspot-v2-pin[data-astro-cid-sqcmh2cm]:after{content:"";position:absolute;top:0;left:0;height:100%;width:100%;background-color:var(--color-sonar);border-radius:50%;pointer-events:none;z-index:-1}.hotspot-v2-pin[data-astro-cid-sqcmh2cm]:before{animation:efecto-sonar 1s ease-out infinite}.hotspot-v2-pin[data-astro-cid-sqcmh2cm]:after{animation:efecto-sonar 1s .5s ease-out infinite}@keyframes efecto-sonar{0%{transform:scale(1);opacity:1}to{transform:scale(3);opacity:0}}.hotspot-v2-tooltip[data-astro-cid-sqcmh2cm]{position:absolute;left:50%;transform:translate(-50%);opacity:0;visibility:hidden;pointer-events:none;transition:opacity .3s ease,visibility .3s ease;z-index:2000;min-width:250px;max-width:500px}.hotspot-v2-tooltip-content[data-astro-cid-sqcmh2cm]{background-color:#eee;color:#444;padding:1rem;border-radius:6px;box-shadow:0 4px 12px #00000026;font-family:Gotham,Helvetica Neue,Helvetica,Arial,sans-serif;font-size:1em;text-align:left}.hotspot-v2-tooltip-content[data-astro-cid-sqcmh2cm] h1[data-astro-cid-sqcmh2cm]{font-size:1.5em;font-weight:600;margin:0 0 .5em;color:#444}.hotspot-v2-tooltip-content[data-astro-cid-sqcmh2cm] p,.hotspot-v2-tooltip-content[data-astro-cid-sqcmh2cm] ul,.hotspot-v2-tooltip-content[data-astro-cid-sqcmh2cm] ol{margin:0 0 .5em;color:#444;line-height:1.5}.hotspot-v2-tooltip-content[data-astro-cid-sqcmh2cm] p:last-child,.hotspot-v2-tooltip-content[data-astro-cid-sqcmh2cm] ul:last-child,.hotspot-v2-tooltip-content[data-astro-cid-sqcmh2cm] ol:last-child{margin-bottom:0}.hotspot-v2-tooltip-content[data-astro-cid-sqcmh2cm] li{margin-bottom:.25em}.hotspot-v2-tooltip-arrow[data-astro-cid-sqcmh2cm]{position:absolute;width:0;height:0;border-style:solid}.hotspot-v2-tooltip[data-astro-cid-sqcmh2cm][data-placement=top]{bottom:calc(100% + 15px)}.hotspot-v2-tooltip[data-astro-cid-sqcmh2cm][data-placement=top] .hotspot-v2-tooltip-arrow[data-astro-cid-sqcmh2cm]{top:100%;left:50%;transform:translate(-50%);border-width:8px 8px 0 8px;border-color:#eee transparent transparent transparent}.hotspot-v2-tooltip[data-astro-cid-sqcmh2cm][data-placement=bottom]{top:calc(100% + 15px)}.hotspot-v2-tooltip[data-astro-cid-sqcmh2cm][data-placement=bottom] .hotspot-v2-tooltip-arrow[data-astro-cid-sqcmh2cm]{bottom:100%;left:50%;transform:translate(-50%);border-width:0 8px 8px 8px;border-color:transparent transparent #eee transparent}.hotspot-v2-tooltip[data-astro-cid-sqcmh2cm][data-placement=left]{right:calc(100% + 15px);left:auto;transform:translate(0);top:50%;margin-top:calc(var(--tam-sonar) / -2)}.hotspot-v2-tooltip[data-astro-cid-sqcmh2cm][data-placement=left] .hotspot-v2-tooltip-arrow[data-astro-cid-sqcmh2cm]{left:100%;top:50%;transform:translateY(-50%);border-width:8px 0 8px 8px;border-color:transparent transparent transparent #eee}.hotspot-v2-tooltip[data-astro-cid-sqcmh2cm][data-placement=right]{left:calc(100% + 15px);transform:translate(0);top:50%;margin-top:calc(var(--tam-sonar) / -2)}.hotspot-v2-tooltip[data-astro-cid-sqcmh2cm][data-placement=right] .hotspot-v2-tooltip-arrow[data-astro-cid-sqcmh2cm]{right:100%;top:50%;transform:translateY(-50%);border-width:8px 8px 8px 0;border-color:transparent #eee transparent transparent}.hotspot-v2-pin[data-astro-cid-sqcmh2cm]:hover+.hotspot-v2-tooltip[data-astro-cid-sqcmh2cm],.hotspot-v2-pin[data-astro-cid-sqcmh2cm]:focus+.hotspot-v2-tooltip[data-astro-cid-sqcmh2cm],.hotspot-v2-point-wrapper[data-astro-cid-sqcmh2cm]:hover .hotspot-v2-tooltip[data-astro-cid-sqcmh2cm]{opacity:1;visibility:visible}.hotspot-v2-tooltip[data-astro-cid-sqcmh2cm]:hover{opacity:1;visibility:visible;pointer-events:all}@media (max-width: 768px){.hotspot-v2[data-astro-cid-sqcmh2cm]{--container-width: 95%}.hotspot-v2-tooltip[data-astro-cid-sqcmh2cm]{min-width:200px;max-width:85vw}.hotspot-v2-tooltip-content[data-astro-cid-sqcmh2cm]{font-size:.95em}.hotspot-v2-tooltip-content[data-astro-cid-sqcmh2cm] h1[data-astro-cid-sqcmh2cm]{font-size:1.3em}}@media (max-width: 480px){.hotspot-v2[data-astro-cid-sqcmh2cm]{--tam-sonar: 12px}.hotspot-v2-tooltip[data-astro-cid-sqcmh2cm]{min-width:180px;max-width:80vw}.hotspot-v2-tooltip-content[data-astro-cid-sqcmh2cm]{font-size:.9em;padding:.75rem}.hotspot-v2-tooltip-content[data-astro-cid-sqcmh2cm] h1[data-astro-cid-sqcmh2cm]{font-size:1.2em}}.enzyme-grid{display:grid;grid-template-columns:repeat(2,1fr);gap:2rem;margin:2rem 0;width:100%}.enzyme-item{display:flex;flex-direction:column;align-items:center;text-align:center;width:100%}.enzyme-item p{margin-bottom:1rem}.enzyme-item figure{width:100%;max-width:100%}@media (max-width: 768px){.enzyme-grid{grid-template-columns:1fr;gap:1.5rem}}.caption{text-align:center;color:#444;font-size:.85rem;line-height:1.1rem;margin-top:.5rem}